The reductions will be effective from 29 April.
For new business, NatWest is cutting rates by up to 33bps and 34bps on selected 2 and 5-year purchase products respectively.
Remortgages will see cuts of up to 14bps and 26bps on selected 2 and 5-year deals, respectively.
First-time buyer products up to 80% LTV will be reduced by 4bps, and within the Green Mortgage range cuts of 1bps and up to 8bps on selected 2 and 5-year fixed will apply.
For cashback 5-year purchase products, rate reductions of up to 24bps on selected deals apply. Within this range for 90% LTV offerings, the lender has reduced rates by 1bps.
Cashback 5-year remortgage products up to 60% LTV will see a 1bps reduction on 29 April.
For existing customers, the lender is increasing rates for switchers by up to 25bps and 15bps on selected 2- and 5-year deals respectively.